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Article

Yeast genes controlling responses to topogenic signals in a model transmembrane protein.

Molecular biology of the cell - 1 Apr 2002

Tipper Donald J, Harley Carol A

Abstract excerpt

Yeast protein insertion orientation (PIO) mutants were isolated by selecting for growth on sucrose in cells in which the only source of invertase is a C-terminal fusion to a transmembrane protein. Only the fraction with an exocellular C terminus can be processed to secreted invertase and this fraction is constrained to 2-3% by a strong charge difference signal. Identified pio mutants increased this to 9-12%. PIO1...

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Identifiers

PMID: 11950929
DOI: 10.1091/mbc.01-10-0488
PMCID: PMC102259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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