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Article

Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products.

FEMS microbiology letters - 19 Feb 2002

Wang Yulong, Niemi Jarmo, Mäntsälä Pekka

Abstract excerpt

The rdm genes B, C and E from Streptomyces purpurascens encode enzymes that tailor aklavinone and aclacinomycins. We report that in addition to hydroxylation of aklavinone to epsilon-rhodomycinone, RdmE (aklavinone-11-hydroxylase) hydroxylated 11-deoxy-beta-rhodomycinone to beta-rhodomycinone both in vivo and in vitro. 15-Demethoxyaklavinone and decarbomethoxyaklavinone did not serve as substrates. RdmC...

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PMID: 11934504
DOI: 10.1111/j.1574-6968.2002.tb11070.x

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