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Article

15 deoxy delta12,14 PGJ2 induces procoagulant activity in cultured human endothelial cells.

Thrombosis and haemostasis - 1 Mar 2002

Xie Shaoping, O'Regan David J, Kakkar Vijay V, Scully Michael F

Abstract excerpt

15 deoxy delta12,14 PGJ2 (15d-PGJ2), a high affinity ligand of peroxisome proliferator-activated receptor gamma (PPARgamma) has been proposed to act as a negative feedback regulator of the inflammatory response. We investigated the effect of 15d-PGJ2 on the anticoagulant property of endothelial cells. 15d-PGJ2 stimulated a moderate but sustained increase in tissue factor (TF) activity in HUVECs and EA.hy926 cells...

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Identifiers

PMID: 11916086

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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