Article
Molecular biology of lung cancer: clinical implications.
Clinics in chest medicine - 1 Mar 2002
Fong Kwun M, Minna John D
Abstract excerpt
This review summarizes the rapidly expanding knowledge of the molecular pathogenesis of lung cancer. It is clear that respiratory epithelial cells require many genetic alterations to become invasive and metastatic cancer. Much more is to be learned, but with modern technology. Clinicians can detect "field cancerized" regions and preneoplastic and malignant cells, therefore offering the opportunity to intercede...
Topics
- Biomarkers, Tumor
- Female
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Growth Substances
- Humans
- Lung Neoplasms
- Male
- Molecular Epidemiology
- Neoplastic Processes
- Proto-Oncogenes
- Risk Factors