Article
Antigenic variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kilodalton protein gene family.
Infection and immunity - 1 Apr 2002
Long S Wesley, Zhang Xiao-Feng, Qi Hai, Standaert Steven, Walker David H, Yu Xue-Jie
Abstract excerpt
The transcriptional activity and allele variation of the 28-kDa outer membrane protein gene (p28) of Ehrlichia chaffeensis were analyzed to determine the mechanism of the antigenic variation of the 28-kDa outer membrane proteins. Reverse transcriptase PCR amplification of mRNA indicated that 16 of the 22 members of the p28 multigene family were transcribed. Amino acid sequence analysis indicated that the p28-19...
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