Article
Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.
Science (New York, N.Y.) - 15 Feb 2002
Trainor Paul A, Ariza-McNaughton Linda, Krumlauf Robb
Abstract excerpt
Cranial neural crest cells generate the distinctive bone and connective tissues in the vertebrate head. Classical models of craniofacial development argue that the neural crest is prepatterned or preprogrammed to make specific head structures before its migration from the neural tube. In contrast, recent studies in several vertebrates have provided evidence for plasticity in patterning neural crest populations....
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