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Article

Unique and overlapping roles for ZipA and FtsA in septal ring assembly in Escherichia coli.

The EMBO journal - 15 Feb 2002

Pichoff Sebastien, Lutkenhaus Joe

Abstract excerpt

ZipA and FtsA are essential division proteins in Escherichia coli that are recruited to the division site by interaction with FtsZ. Utilizing a newly isolated temperature-sensitive mutation in zipA we have more fully characterized the role of ZipA. We confirmed that ZipA is not required for Z ring formation; however, we found that ZipA, like FtsA, is required for recruitment of FtsK and therefore all downstream...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11847116
DOI: 10.1093/emboj/21.4.685
PMCID: PMC125861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Unique and overlapping roles for ZipA and FtsA in septal ring assembly in Escherichia coli.PMID 11847116Read ↗

A gain-of-function mutation in ftsA bypasses the requirement for the essential cell division gene zipA in Escherichia coli.Semantic proximity Read ↗

Direct binding of FtsZ to ZipA, an essential component of the septal ring structure that mediates cell division in E. coli.Semantic proximity Read ↗

The bypass of ZipA by overexpression of FtsN requires a previously unknown conserved FtsN motif essential for FtsA-FtsN interaction supporting a model in which FtsA monomers recruit late cell division proteins to the Z ring.Semantic proximity Read ↗

The ftsA* gain-of-function allele of Escherichia coli and its effects on the stability and dynamics of the Z ring.Semantic proximity Read ↗

Identification of a region of FtsA required for interaction with FtsZ.Semantic proximity Read ↗

FtsA is localized to the septum in an FtsZ-dependent manner.Semantic proximity Read ↗

ZipA Uses a Two-Pronged FtsZ-Binding Mechanism Necessary for Cell Division.Semantic proximity Read ↗

A mutation in Escherichia coli ftsZ bypasses the requirement for the essential division gene zipA and confers resistance to FtsZ assembly inhibitors by stabilizing protofilament bundling.Semantic proximity Read ↗

Peptide Linkers within the Essential FtsZ Membrane Tethers ZipA and FtsA Are Nonessential for Cell Division.Semantic proximity Read ↗

FtsA mutants impaired for self-interaction bypass ZipA suggesting a model in which FtsA's self-interaction competes with its ability to recruit downstream division proteins.Semantic proximity Read ↗

A role for the FtsQLB complex in cytokinetic ring activation revealed by an ftsL allele that accelerates division.Semantic proximity Read ↗

FtsZ-ZapA-ZapB interactome of Escherichia coli.Semantic proximity Read ↗

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