Article
DAP12 ITAM motif regulates differentiation and apoptosis in M1 leukemia cells.
Biochemical and biophysical research communications - 22 Feb 2002
Aoki Naoko, Kimura Shoji, Oikawa Kensuke, Nochi Hitoshi, Atsuta Yoshiaki, Kobayashi Hiroya, Sato Keisuke, Katagiri Makoto
Abstract excerpt
DAP12 is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing transmembrane adapter molecule that is associated with the NK-activating receptors. DAP12 is expressed not only in NK cells, but also in myeloid cells. Previously, we reported that DAP12 was likely to be involved in monocyte differentiation to macrophage. In this study, we established the mutant DAP12-M1 transfectants (Y76F-M1) that have...
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