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Article

HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy

1 Feb 2002

Abstract excerpt

Different mechanisms mediated by the expression of the HLA-class Ib HLA-G products are suggested to account for the induction of immune tolerance against the paternal antigens of the fetus during pregnancy. Soluble HLA-G antigens, mainly produced by cytotrophoblast cells at the materno-fetal interface and circulating in the body fluids, show a capacity analogous to that of membrane-boundstructures to inhibit NK...

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PMID: 11807769
DOI: 10.1002/1521-4141(200202)32:2<311::aid-immu311>3.0.co;2-8

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