Article
[Mechanisms of metastasis].
Therapeutische Umschau. Revue therapeutique - 1 Dec 2001
Burger M M
Abstract excerpt
Until a primary tumor can successfully produce clinically relevant metastases, the seed cells have to go through a series of stepwise changes (mutations) which have to overcome a sizeable cascade of obstacles. Some of the experimentally proven and clinically suspected changes involve cell surface adhesion, general and local growth factor responsiveness, protease and glycosidase production, motility and...
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