Article
[Multicenter study in southern South America of the in vitro activity of telithromycin in strains with defined resistance phenotypes isolated from community-acquired respiratory infections].
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia - 1 Sept 2001
Casellas J M, Visser M, Mac Dougall N, Coco B, Tomé G, Gliosca L
Abstract excerpt
Telithromycin was the first ketolide to be approved in Europe and is in the approval process in the United States. It is structurally related to the macrolides; it has a keto group in the C3 position rather than cladinose. A carbamate group is also present at C11-C12. As a result, it has a reduced induction of the MLSB resistance mechanism (erm gene), it is not affected by the flux mechanism (mef gene), it has...
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