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Article

Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.

Molecular biology and evolution - 1 Jan 2002

Sanderson Michael J

Abstract excerpt

Rates of molecular evolution vary widely between lineages, but quantification of how rates change has proven difficult. Recently proposed estimation procedures have mainly adopted highly parametric approaches that model rate evolution explicitly. In this study, a semiparametric smoothing method is developed using penalized likelihood. A saturated model in which every lineage has a separate rate is combined with a...

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PMID: 11752195
DOI: 10.1093/oxfordjournals.molbev.a003974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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