Article
Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection.
Journal of the American Society of Nephrology : JASN - 1 Jan 2002
Shahbazi Majid, Fryer Anthony A, Pravica Vera, Brogan Iain J, Ramsay Helen M, Hutchinson Ian V, Harden Paul N
Abstract excerpt
Acute rejection is a major cause of reduced survival of renal allografts. Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells and is expressed widely by renal tissue and T cells. VEGF influences adhesion and migration of leukocytes across the endothelium. This study investigates whether genetically determined variation in VEGF expression influences the development of renal allograft...
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