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Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity

15 Dec 2001

Abstract excerpt

ORF74 (or KSHV-vGPCR) is a highly constitutively active G protein-coupled receptor encoded by HHV8 that is regulated both positively and negatively by endogenous chemokines. When expressed in transgenic mice, this chemokine receptor induces an angioproliferative disease closely resembling Kaposi sarcoma (KS). Here we demonstrate that several lines of mice carrying mutated receptors deficient in either...

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PMID: 11748262
DOI: 10.1172/jci13622

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