Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.

doi:10.1038/sj.onc.1204799

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Article

Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.

Oncogene - 11 Oct 2001

Koul D, Parthasarathy R, Shen R, Davies M A, Jasser S A, Chintala S K, Rao J S, Sun Y, Benvenisite E N, Liu T J, Yung W K

Abstract excerpt

Human gliomas are highly invasive, and remain to be a major obstacle for any effective therapeutic remedy. Among many other factors, gliomas express elevated levels of matrix metalloproteinases (MMPs), which have been implicated to play an important role in tumor invasion as well as neovascularization. The tumor suppressor gene mutated in multiple advanced cancers/phosphatase and tensin homologue (MMAC/PTEN) has...

Read the complete abstract on PubMed

Topics

Anoikis
Cell Division
Genes, Reporter
Glioma
Humans
Immunoblotting
Luciferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Matrix Metalloproteinase 2

Matrix Metalloproteinase Inhibitors

Microscopy, Phase-Contrast

Neoplasm Invasiveness

PTEN Phosphohydrolase

Phenotype

Phosphoric Monoester Hydrolases

Plasmids

Promoter Regions, Genetic

RNA

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 11709701
DOI: 10.1038/sj.onc.1204799

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.