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Article

Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor.

The Journal of clinical endocrinology and metabolism - 1 Nov 2001

Ando S, Sarlis N J, Oldfield E H, Yen P M

Abstract excerpt

In patients with TSH-secreting tumors (TSHomas), serum TSH is poorly suppressed by thyroid hormone. The mechanism for this defect in negative regulation of TSH secretion is not known. To investigate the possibility of a somatic mutation of TR causing this defect, we performed mutational analysis of TRbeta by RT-PCR using RNA obtained from five surgically resected TSHomas. In one TSHoma, we identified a somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Thyroid Hormone

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Source

Identifiers

PMID: 11701737
DOI: 10.1210/jcem.86.11.7984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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