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Article

Enhanced cell polarity in mutants of the budding yeast cyclin-dependent kinase Cdc28p.

Molecular biology of the cell - 1 Nov 2001

Ahn S H, Tobe B T, Fitz Gerald J N, Anderson S L, Acurio A, Kron S J

Abstract excerpt

The yeast cyclin-dependent kinase Cdc28p regulates bud morphogenesis and cell cycle progression via the antagonistic activities of Cln and Clb cyclins. Cln G1 cyclins direct polarized growth and bud emergence, whereas Clb G2 cyclins promote isotropic growth of the bud and chromosome segregation. Using colony morphology as a screen to dissect regulation of polarity by Cdc28p, we identified nine point mutations...

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Share to CDC28 Protein Kinase, S cerevisiae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11694591
DOI: 10.1091/mbc.12.11.3589
PMCID: PMC60278

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