Article
Genetic insights into the neurodevelopmental hypothesis of schizophrenia.
Schizophrenia bulletin - 1 Jan 2001
Bassett A S, Chow E W, O'Neill S, Brzustowicz L M
Abstract excerpt
The original neurodevelopmental hypothesis of schizophrenia presented by D.R. Weinberger in 1987 focused on pathogenesis and did not address etiology. Available evidence indicates that genetic factors are the principal cause of schizophrenia. It is imperative that any pathogenetic model for schizophrenia takes into account what is now known about genetic mechanisms of illness. Recent advances in molecular...
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