Article
Activity of ertapenem (MK-0826) versus Enterobacteriaceae with potent beta-lactamases.
Antimicrobial agents and chemotherapy - 1 Oct 2001
Livermore D M, Oakton K J, Carter M W, Warner M
Abstract excerpt
Ertapenem (MK-0826; L-749,345), a new carbapenem with a long serum half-life, was tested, in vitro, against beta-lactamase-producing bacteria. The new compound had a MIC at which 90% of the isolates were inhibited of 0.06 microg/ml for extended-spectrum beta-lactamase (ESBL)-producing klebsiellas, compared with 0.5 microg/ml for imipenem, 16 microg/ml for cefepime, and >128 microg/ml for ceftazidime and...
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