Article
Cell cycle activation of peripheral blood stem and progenitor cells expanded ex vivo with SCF, FLT-3 ligand, TPO, and IL-3 results in accelerated granulocyte recovery in a baboon model of autologous transplantation but G0/G1 and S/G2/M graft cell content does not correlate with transplantability.
Stem cells (Dayton, Ohio) - 1 Jan 2001
Drouet M, Herodin F, Norol F, Mourcin F, Mayol J F
Abstract excerpt
Ex vivo expansion is a new strategy for hematopoietic stem and progenitor cell transplantation based on cytokine-induced amplification to produce grafts of controlled maturity. If the cell cycle position of CD34(+) cells has been reported to govern their engraftment potential, the respective role of stem and progenitor cells in short- and long-term hematopoietic recovery remains debated. Studies focused on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.