Article
No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility.
Diabetes/metabolism research and reviews - 1 Jan 2000
Pociot F, Larsen Z M, Zavattari P, Deidda E, Nerup J, Cattaneo M, Chiaramonte R, Comi P, Sabbadini M, Zollo M, Biunno I, Cucca F
Abstract excerpt
BACKGROUND: The SEL1L gene is located on human chromosome 14q24.3-31 close to D14S67 which has been previously proposed to be a type 1 diabetes mellitus locus (IDDM11). Sel-1 is a negative regulator of the Notch signalling pathway and SEL1L is selectively expressed in adult pancreas and islets of Langerhans. This suggests that SEL1L may be a candidate gene for IDDM11. METHODS: We have analysed two newly...
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