Article
A polymorphic marker for the human cathepsin B gene.
Molecular and cellular probes - 1 Aug 2001
MacKenzie J R, Mason S L, Hickford J G, Kohonen-Corish M R, Bickerstaffe R
Abstract excerpt
Human cathepsin B (CTSB) is a proteolytic enzyme implicated in tumor invasion and metastasis. We describe a PCR-based polymorphic marker for this gene comprising two amplimers differing in length by 19 consecutive nucleotides in intron 7, near the exon 8 splice acceptor site, identifying two gene alleles (A and B). Allele frequencies were 0.614 for A and 0.386 for the B allele, with an observed heterozygosity of...
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