Article
A phenotypic change of small intestinal epithelium to colonocytes in small intestinal adenomas and adenocarcinomas.
The American journal of gastroenterology - 1 Aug 2001
Onuma E K, Amenta P S, Jukkola A F, Mohan V, Borra S, Das K M
Abstract excerpt
OBJECTIVE: Using a novel monoclonal antibody (mAb Das-1) that specifically reacts with colon epithelium, we examined if there is a phenotypic change of small intestinal enterocytes toward colonocytes in small intestinal neoplastic tissue. METHODS: Tissue sections of the small intestine consisting of adenomas (n = 20, five with histories of familial polyposis), adenocarcinomas (eight primary and one metastatic...
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