Article
Pathogenesis: immunogenetic factors.
Best practice & research. Clinical rheumatology - 1 Jun 2001
Huang D, Zhou Y, Hoffman G S
Abstract excerpt
The occurrence, albeit infrequent, of systemic vasculitis in closely related family members suggests that both environmental and genetic factors may play a role in the pathogenesis of these diseases. Malfunction of immune regulation in the systemic vasculitides may indicate a role for genes that encode molecules critical to the immune responses. The extremely polymorphic sequences of MHC molecules may provide a...
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