Article
Molecular mechanisms of hypo- and afibrinogenemia.
Annals of the New York Academy of Sciences - 1 Jan 2001
Brennan S O, Fellowes A P, George P M
Abstract excerpt
Point mutations responsible for hypo- and afibrinogenemia are yielding new insights into amino acid side chains involved in the molecular processing, assembly, secretion, and domain stability of fibrinogen. Reverse phase chromatography, isoelectric focussing, electrospray mass spectrometry, and tryptic peptide mass mapping have shown that chains with heterozygous mutations of gamma 284 Gly-->Arg, B beta 316...
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