Article
A powerful and rapid approach to human genome scanning using small quantities of genomic DNA.
Genetical research - 1 Apr 2001
Beekman M, Lakenberg N, Cherny S S, de Knijff P, Kluft C C, van Ommen G J, Vogler G P, Frants R R, Boomsma D I, Slagboom P E
Abstract excerpt
Dense maps of short-tandem-repeat polymorphisms (STRPs) have allowed genome-wide searches for genes involved in a great variety of diseases with genetic influences, including common complex diseases. Generally for this purpose, marker sets with a 10 cM spacing are genotyped in hundreds of individuals. We have performed power simulations to estimate the maximum possible intermarker distance that still allows for...
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