Article
Time-dependent expression of intestinal phenotype in signet ring cell carcinomas of the human stomach.
Virchows Archiv : an international journal of pathology - 1 Jan 2001
Bamba M, Sugihara H, Kushima R, Okada K, Tsukashita S, Horinouchi M, Hattori T
Abstract excerpt
Signet ring cell carcinomas of the stomach are thought to arise from the proper gastric mucosa without intestinal metaplasia. It was recently reported that intestinal phenotypes appear along with tumor progression. In this study, we performed several experiments to reconsider the significance of this intestinalization in the growth of signet ring cell carcinoma. We applied mucin histochemistry with monoclonal...
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