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Article

Multiple skeletal muscle mitochondrial DNA deletions in patients with unilateral peripheral arterial disease

1 Nov 2000

Abstract excerpt

Peripheral arterial disease (PAD) is associated with metabolic derangements and accumulation of the common 4977 bp mitochondrial DNA (mtDNA) deletion mutation. The current study was undertaken to test the hypothesis that PAD is associated with multiple mtDNA deletions. Gastrocnemius biopsies were obtained from nine patients with unilateral PAD. DNA extracted from the biopsies was analyzed for mtDNA deletions...

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PMID: 11213234
DOI: 10.1177/1358836x0000500405

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