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Article

The neutral theory in an infinite population.

Gene - 30 Dec 2000

Gillespie J H

Abstract excerpt

Selective substitutions at one locus induce stochastic dynamics at a linked neutral locus that resemble genetic drift even when the population size is infinite. This new stochastic force, which is called genetic draft, causes genetic variation at the neutral locus to decrease with population size and the rate of deleterious substitution to increase with population size. The fact that heterozygosities in natural...

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Identifiers

PMID: 11164032
DOI: 10.1016/s0378-1119(00)00485-6

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