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Article

Increased readthrough transcription across the simian virus 5 M-F gene junction leads to growth defects and a global inhibition of viral mRNA synthesis.

Journal of virology - 1 Mar 2001

Parks G D, Ward K R, Rassa J C

Abstract excerpt

Recombinant simian virus 5 (rSV5) mutants containing substitutions in the M-F intergenic region were generated to determine the effect of increased readthrough transcription on the paramyxovirus growth cycle. We have previously shown, using an SV5 dicistronic minigenome, that replacement of the 22-base M-F intergenic region with a foreign sequence results in a template (Rep22) that directs very high levels of M-F...

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Identifiers

PMID: 11160725
DOI: 10.1128/JVI.75.5.2213-2223.2001
PMCID: PMC114805

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