Article
Influence of glutathione S-transferase M1 and T1 genotypes on larynx cancer risk among Korean smokers.
Clinical chemistry and laboratory medicine - 1 Sept 2000
Hong Y J, Lee J K, Lee G H, Hong S I
Abstract excerpt
Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of major carcinogens present in tobacco smoke. It is thus conceivable that deficiency in GST activity due to homozygous deletions of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The influence of the GSTM1 and GSTT1 null genotypes on larynx cancer risk among the Korean population...
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