Article
Latitude-correlated genetic polymorphisms: selection or gene flow?
Human biology - 1 Aug 2000
Ciminelli B M, Jodice C, Scozzari R, Corbo R M, Nahum M, Pompei F, Santachiara-Benerecetti S A, Santolamazza C, Morpurgo G P, Modiano G
Abstract excerpt
Latitude-correlated polymorphisms can be due to either selection-driven evolution or gene flow. To discriminate between them, we propose an approach that studies subpopulations springing from a single population that have lived for generations at different latitudes and have had a low genetic admixture. These requirements are fulfilled to a large extent by Ashkenazi and Sephardi Jews. The original population...
Topics
- Altitude
- Blood Proteins
- Discriminant Analysis
- Emigration and Immigration
- Gene Frequency
- Geography
- Haplotypes
- Humans
- Italy
- Jews
- Phenotype
- Phosphoglucomutase
- Phosphoric Monoester Hydrolases
- Polymorphism, Genetic