Identification oftgh-2, a Filarial Nematode Homolog ofCaenorhabditis elegans daf-7and Human Transforming Growth Factor β, Expressed in Microfilarial and Adult Stages ofBrugia malayi

Abstract excerpt

A novel member of the transforming growth factor beta (TGF-beta) family has been identified in the filarial nematode parasite Brugia malayi by searching the recently developed Expressed Sequence Tag (EST) database produced by the Filarial Genome Project. Designated tgh-2, this new gene shows most similarity to a key product regulating dauer larva formation in Caenorhabditis elegans (DAF-7) and to the human...

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