Article
Analyses of cross species polymerase chain reaction products to infer the ancestral state of human polymorphisms.
DNA sequence : the journal of DNA sequencing and mapping - 1 Jan 1998
Iyengar S, Seaman M, Deinard A S, Rosenbaum H C, Sirugo G, Castiglione C M, Kidd J R, Kidd K K
Abstract excerpt
In numerous population genetic and disease association studies decisions about the ancestry of polymorphic alleles are often made based on the relative frequency of the alleles in the extant populations with the most frequent allele being deemed as ancestral. However, the frequency of an allele in a population is generally not a perfect indicator of its ancestral status. A more accurate method to assess...
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