Article
Molecular genetics of human prion diseases in Germany.
Human genetics - 1 Sept 1999
Windl O, Giese A, Schulz-Schaeffer W, Zerr I, Skworc K, Arendt S, Oberdieck C, Bodemer M, Poser S, Kretzschmar H A
Abstract excerpt
Human prion diseases may be acquired as infectious diseases, they may be inherited in an autosomal dominant fashion or occur sporadically. Mutations and polymorphisms in the sequence of the coding region of the prion protein gene (PRNP) have been established as an important factor in all of these three types of prion diseases. Therefore, a total of 578 patients with suspect prion diseases referred to the German...
Topics
- DNA
- DNA Mutational Analysis
- Genotype
- Germany
- Humans
- Incidence
- Mutagenesis, Insertional
- Mutation
- Mutation, Missense
- Polymorphism, Genetic
- Prion Diseases
- Prions