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Article

Novel syndromic form of X-linked complicated spastic paraplegia

1 Jan 2000

Abstract excerpt

This study presents a family with a syndromic form of X-linked mental retardation in which four males in two generations present severe mental retardation, slowly progressive spastic paraplegia, facial hypotonia, and maxillary hypoplasia. Multipoint linkage analysis with 24 highly polymorphic markers indicated two possible candidate regions: Xp21.1-Xq21.3 (flanking markers DXS1214 and DXS990) and Xq23-Xq27.1...

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PMID: 10982473
DOI: 10.1002/1096-8628(20000904)94:1<1::aid-ajmg1>3.0.co;2-v

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