Challenges in the development of an effective HIV vaccine: current approaches and future directions.

Abstract excerpt

OBJECTIVE: The intent of this review is to investigate and discuss why developing a successful HIV vaccine has been so challenging, first by examining the molecular biology of the virus and how HIV interacts with the immune system, and then reviewing past viral vaccine successes as well as future directions for HIV vaccine research. BACKGROUND: Since HIV appeared in the United States in the early 1980s, an...

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