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Genetics of Fracture: Challenges and Opportunities

1 Jul 2000

Abstract excerpt

Over the past 30 years or so epidemiological and genetic studies have consistently shown that bone mineral density (BMD), a measure of bone strength, is a primary determinant of fracture risk in the general population 1-4; that a large component of the variance of BMD (up to 80%) is determined by genetic factors5-9; and that a family history of fracture confers significant increase in risk of fracture for a...

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PMID: 10893673
DOI: 10.1359/jbmr.2000.15.7.1253

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