Article
A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension.
American journal of human genetics - 1 Aug 2000
Disse-Nicodème S, Achard J M, Desitter I, Houot A M, Fournier A, Corvol P, Jeunemaitre X
Abstract excerpt
Pseudohypoaldosteronism type II (PHA2) is a rare autosomal dominant form of volume-dependent low-renin hypertension characterized by hyperkalemia and hyperchloremic acidosis but also by a normal glomerular filtration rate. These features, together with the correction of blood pressure and metabolic abnormalities by small doses of thiazide diuretics, suggest a primary renal tubular defect. Two loci have previously...
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