Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pyruvate dehydrogenase kinase from Arabidopsis thaliana: a protein histidine kinase that phosphorylates serine residues.

The Biochemical journal - 1 Jul 2000

Thelen J J, Miernyk J A, Randall D D

Abstract excerpt

Pyruvate dehydrogenase kinase (PDK) is the primary regulator of flux through the mitochondrial pyruvate dehydrogenase complex (PDC). Although PDKs inactivate mitochondrial PDC by phosphorylating specific Ser residues, the primary amino acid sequence indicates that they are more closely related to prokaryotic His kinases than to eukaryotic Ser/Thr kinases. Unlike Ser/Thr kinases, His kinases use a conserved His...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Aspartic Acid
Share to Glutamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histidine

Share to Histidine Kinase

Share to Pyruvate Dehydrogenase Acetyl-Transferring Kinase

Share to Serine

Share to Trypsin

Source

Open in PubMed Open full text

Identifiers

PMID: 10861228
DOI: 10.1042/0264-6021:3490195
PMCID: PMC1221137

Genes

PDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pyruvate dehydrogenase kinase from Arabidopsis thaliana: a protein histidine kinase that phosphorylates serine residues.PMID 10861228Read ↗

Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis.Semantic proximity Read ↗

Probing the mechanism of inactivation of human pyruvate dehydrogenase by phosphorylation of three sites.Semantic proximity Read ↗

Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases.Semantic proximity Read ↗

A heteromeric plastidic pyruvate kinase complex involved in seed oil biosynthesis in Arabidopsis.Semantic proximity Read ↗

Two mitochondrial phosphatases, PP2c63 and Sal2, are required for posttranslational regulation of the TCA cycle in Arabidopsis.Semantic proximity Read ↗

Specificity determinants for the pyruvate dehydrogenase component reaction mapped with mutated and prosthetic group modified lipoyl domains.Semantic proximity Read ↗

Effects of antisense repression of an Arabidopsis thaliana pyruvate dehydrogenase kinase cDNA on plant development.Semantic proximity Read ↗

Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity.Semantic proximity Read ↗

Molecular cloning and characterization of ATP-phosphoribosyl transferase from Arabidopsis, a key enzyme in the histidine biosynthetic pathway.Semantic proximity Read ↗

Swiveling domain mechanism in pyruvate phosphate dikinase.Semantic proximity Read ↗

Serine/threonine kinase activity in the putative histidine kinase-like ethylene receptor NTHK1 from tobacco.Semantic proximity Read ↗

Serine/threonine/tyrosine protein kinase from Arabidopsis thaliana is dependent on serine residues for its activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.