Article
DNA chips: the future of biomarkers.
The International journal of biological markers - 1 Jan 2000
De Benedetti V M, Biglia N, Sismondi P, De Bortoli M
Abstract excerpt
DNA chips are small, solid supports such as microscope slides onto which thousands of cDNAs or oligonucleotides are arrayed, representing known genes or simply EST clones, or covering the entire sequence of a gene with all its possible mutations. Fluorescently labeled DNA or RNA extracted from tissues is hybridized to the array. Laser scanning of the chip permits quantitative evaluation of each individual...
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