Article
Practical and theoretical issues in gene-targeting studies and their application to behaviour.
Reviews in the neurosciences - 1 Jan 2000
Hagan J J, Harper A J, Elliott H, Jones D N, Rogers D C
Abstract excerpt
Some of the major practical and theoretical issues that are associated with gene-targeting studies in mice are discussed. The availability of sufficient space to house the extensive breeding colonies associated with studies in gene-manipulated mice is an important logistical consideration that requires consideration at an early stage. A practical example is discussed which illustrates some of these issues....
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