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Article

Genetic variation: molecular mechanisms and impact on microbial evolution.

FEMS microbiology reviews - 1 Jan 2000

Arber W

Abstract excerpt

On the basis of established knowledge of microbial genetics one can distinguish three major natural strategies in the spontaneous generation of genetic variations in bacteria. These strategies are: (1) small local changes in the nucleotide sequence of the genome, (2) intragenomic reshuffling of segments of genomic sequences and (3) the acquisition of DNA sequences from another organism. The three general...

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PMID: 10640595
DOI: 10.1111/j.1574-6976.2000.tb00529.x

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