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Article

Region of factor IXa protease domain that interacts with factor VIIIa: analysis of select hemophilia B mutants.

Thrombosis and haemostasis - 1 Aug 1999

Bajaj S P

Abstract excerpt

Essential to hemostasis is the interaction of factor IXa with factor VIIIa. Recent studies indicate that helix-330 in the protease domain of factor IXa provides a critical binding site for factor VIIIa. Although weaker interactions cannot be ruled out, a primary role of the EGF1 domain of factor IXa in this context may be to serve as a spacer in properly positioning the factor IXa protease domain for optimal...

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PMID: 10605707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Region of factor IXa protease domain that interacts with factor VIIIa: analysis of select hemophilia B mutants.PMID 10605707Read ↗

Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa.Semantic proximity Read ↗

Hemophilia B caused by five different nondeletion mutations in the protease domain of factor IX.Semantic proximity Read ↗

[Significance of mutation analysis in patients with haemophilia A].Semantic proximity Read ↗

Experimental and theoretical evidence supporting the role of Gly363 in blood coagulation factor IXa (Gly193 in chymotrypsin) for proper activation of the proenzyme.Semantic proximity Read ↗

Amino acid substitutions in the factor VIII coagulation protein that cause hemophilia A in man.Semantic proximity Read ↗

Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex.Semantic proximity Read ↗

Factor IX Fukuoka. Substitution of ASN92 by His in the second epidermal growth factor-like domain results in defective interaction with factors VIIa/X.Semantic proximity Read ↗

Identification of haemophilia B patients with mutations in the two calcium binding domains of factor IX: importance of a beta-OH Asp 64----Asn change.Semantic proximity Read ↗

Mutations in the catalytic domain of factor IX that are related to the subclass hemophilia Bm.Semantic proximity Read ↗

Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity.Semantic proximity Read ↗

Interaction of factor IXa with factor VIIIa. Effects of protease domain Ca2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X.Semantic proximity Read ↗

Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa.Semantic proximity Read ↗

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