Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking.

doi:10.1074/jbc.274.48.34389

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Article

Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking.

The Journal of biological chemistry - 26 Nov 1999

Munro T P, Magee R J, Kidd G J, Carson J H, Barbarese E, Smith L M, Smith R

Abstract excerpt

Cytoplasmic transport and localization of mRNA has been reported for a range of oocytes and somatic cells. The heterogeneous nuclear ribonucleoprotein (hnRNP) A2 response element (A2RE) is a 21-nucleotide segment of the myelin basic protein mRNA that is necessary and sufficient for cytoplasmic transport of this message in oligodendrocytes. The predominant A2RE-binding protein in rat brain has previously been...

Topics

Animals
Animals, Newborn
Base Sequence
Binding Sites
Biological Transport
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
Heterogeneous-Nuclear Ribonucleoproteins
Humans
Mice
Mice, Inbred C57BL

Microscopy, Confocal

Mutation

Myelin Basic Protein

Oligodendroglia

Oligonucleotides

Oligonucleotides, Antisense

Point Mutation

Protein Binding

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