A DNA Sequence Corresponding to the Gene Encoding Cysteine Proteinase 5 in Entamoeba histolytica Is Present and Positionally Conserved but Highly Degenerated in Entamoeba dispar

Abstract excerpt

Cysteine proteinases of Entamoeba histolytica are considered to be one of the most important classes of molecules responsible for the parasite's ability to destroy human tissues. Interestingly, one particular cysteine proteinase, located on the surface of E. histolytica trophozoites and designated cysteine proteinase 5 (CP5), is not expressed in the closely related but nonpathogenic species Entamoeba dispar. By...

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