Article
No interaction between serotonin transporter gene and dopamine receptor D4 gene in symptomatology of major psychoses.
American journal of medical genetics - 15 Oct 1999
Serretti A, Cusin C, Lattuada E, Lilli R, Lorenzi C, Di Bella D, Catalano M, Smeraldi E
Abstract excerpt
Previously, we reported an association of the dopamine receptor D4 (DRD4) gene with delusional symptomatology of major psychoses. However, DRD4 variants accounted for only 2% of the phenotypic variance, indicating that contributions from other genes were probable. The serotonin transporter gene is a primary candidate in major psychoses, and a functional polymorphism in the upstream regulatory region of the...
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