Article
Reduced expression of the G209A alpha-synuclein allele in familial Parkinsonism.
Annals of neurology - 1 Sept 1999
Markopoulou K, Wszolek Z K, Pfeiffer R F, Chase B A
Abstract excerpt
Missense mutations at the alpha-synuclein gene have been associated with familial parkinsonism. We report that the phenotype of a kindred (Family H) with autosomal dominant, levodopa-responsive parkinsonism maps to chromosomal region 4q21-23 and that affected members of this kindred harbor a previously reported mutation (G209A) in exon 4 of the alpha-synuclein gene. We assessed the expression of the G209A allele...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.