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Induction of Stress Genes by Low Doses of Gamma Rays

1 Sept 1999

Abstract excerpt

Using cells of a human myeloid tumor cell line (ML-1), we have detected induction of several stress-responsive genes by doses of gamma rays below 50 cGy. We found a linear dose-response relationship for induction of CDKN1A (formerly known as CIP1/WAF1) and GADD45 mRNA levels over the range of 2-50 cGy, with no evidence of a threshold for induction. Although exposures to 2 and 5 cGy did not result in any...

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PMID: 10453082
DOI: 10.2307/3580321

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