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Article

A search for the possible molecular mechanisms of thyroid dysgenesis: sex ratios and associated malformations.

The Journal of clinical endocrinology and metabolism - 1 Jul 1999

Devos H, Rodd C, Gagné N, Laframboise R, Van Vliet G

Abstract excerpt

Permanent primary congenital hypothyroidism (CH) can be caused by abnormal thyroid differentiation (athyreosis), migration (ectopy), or function (leading to goiter). Goiters follow an autosomal recessive pattern of inheritance, whereas ectopy and athyreosis are considered as a single sporadic entity with a female preponderance. On the other hand, a high prevalence of extrathyroidal malformations has been reported...

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Identifiers

PMID: 10404827
DOI: 10.1210/jcem.84.7.5831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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